Classification of endometrial adenocarcinoma using histopathology images with extreme learning machine method

Abstract

As many as 70-80% of endometrial cancer cases are endometrial adenocarcinoma. Histopathological assessment is based on the degree of differentiation, into well-differentiated, moderate-differentiated, and poorly-differentiated. Management and prognosis differ between grades, so differential diagnosis in determining the degree of tumor differentiation is crucial for appropriate treatment decisions. Histopathological image analysis offers detailed diagnostic results, but manual analysis by a pathologist is very complicated, error-prone, quite tedious, and time-consuming. Therefore, an automatic diagnostic system is needed to assist pathologists in grading the tumor. This research aims to determine the degree of differentiation of endometrial adenocarcinoma based on histopathological images. The extreme learning machine (ELM) method performs image classification with gray level run long matrix (GLRLM) features and a combination of local binary pattern (LBP)-GLRLM features as input. Experimental results show that the ELM model can achieve satisfactory performance. Training accuracy, testing accuracy, and model precision with GLRLM features were 97.13%, 91.33%, and 80% and combined LBPGLRLM features were 91.03%, 71.33%, and 100%. Overall, the model created can determine the degree of tumor differentiation and is useful in providing a second opinion for pathologists.