Three-wavelength System for Practical Application in Skin Oximetry: Simultaneous Equations with Prediction-correction Approach

Audrey Huong, W. Mahani Hafizah W. Mahmud, Xavier Ngu

Abstract


This paper presented the use of a three-wavelength system coupled with a prediction-correction model for the measurement of a person’s tissue oxygen levels and in the efforts towards the development of a field-portable system. This study considered light wavelength of market-available emitters in the range 500 − 650 nm for its practical implementation. This approach required the use of light attenuation and hemoglobin absorptivity information of three different wavelengths in determining tissue oxygen saturation value, StO2. It was found through the analysis of results using Monte Carlo method that considerable improvement in the accuracy of the predictions was obtained using the corrective models (ρ =0.874). The low mean prediction errors of similar magnitude, not exceeding 4 %, given by two wavelength combinations 538, 560, 633 nm and 538, 560, 650 nm were observed for signals with signal-noise ratio (SNR) of down to 30 dB. A significant statistical difference was found between the prediction errors and the wavelength combination used under this noise condition (ρ =0.011). This work concluded that the findings of this study provide insights into technology implementation of skin oximetry and the possible impacts it might have in medical arena.


Keywords


Corrective model; Three wavelengths; Tissue oxygen saturation; Skin oximetry; Simultaneous equations

References


M. Welter, T. Fredrich, H. Rinneberg and H. Rieger, “Computational model for tumor oxy¬genation applied to clinical data on breast tumor hemoglobin concentrations suggests vascular dilatation and compression,” PLOS ONE, vol. 11, pp. 1-42, 2016.

P.K. Upputuri, K. Sivasubramanian, S.K. Chong and M. Pramanik, “Recent developments in vascular imaging techniques in tissue engineering and regenerative medicine,” BioMed Research International, vol. 2015 pp. 1-10, 2015.

C.K. Sen, S. Ghatak, S.C. Gnyawali, S. Roy and G.M. Gordillo, “Cutaneous imaging technologies in acute burn and chronic wound care,” Plast Reconstr Surg., vol.138, pp. 1-20, 2016.

L. Meng, F. Settecase, J. Xiao, Z. Yu, A.M. Flexman and R.T. Higashida, “Initial clinical experience with near-infrared spectroscopy in assessing cerebral tissue oxygen saturation in cerebral vasospasm before and after intra-arterial verapamil injection,” AIP: Review of Scientific Instruments, vol.13, pp. 1-12, 1942.

I.Y. Petrov, R.A. Fonseca, C.J. Richardson, Y. Petrov, D.S. Prough, A. Petrov, K.E. Wynne, S. Westermann and R.O. Esenaliev, “Monitoring cerebral venous blood oxygenation in neonates with a medical-grade optoacoustic system,” in Proc. SPIE 9323: Photons Plus Ultrasound: Imaging and Sensing, vol.9323, pp. 1-5, 2015.

S.G. Demos, A.J. Vogel and A.H. Gandjbakhche, “Advances in optical spectroscopy and imaging of breast lesions,” J Mammary Gland Biol Neoplasia, vol.11, pp.165-181, 2006.

H. Ito, I. Kanno, H. Iida, J. Hatazawa, E. Shimosegawa, H. Tamura and T. Okudera, “Arterial fraction of cerebral blood volume in humans measured by positron emission tomography,” Ann Nucl Med, vol. 15, pp. 111-6, 2001.

C. Hsu, S. Tzeng, C. Yang, J.Y. Lee, L.L. Huang, W. Chen, M. Hughes, Y. Chen, Y. Liao and S. Tseng, “Non-invasive evaluation of therapeutic response in keloid scar using diffuse reflectance spectroscopy,” Biomedical Optics Express, vol. 6, pp. 390-404, 2015.

A. Huong, S. Philimon and X. Ngu, “Multispectral imaging of acute wound tissue oxygenation,” Journal of Innovative Optical Health Sciences, vol.10, pp.17500041-8, 2017.

A. Becker, M. Masthoff, J. Claussen, S.J. Ford, W. Roll, M. Burg, P.J. Barth, W. Heindel, M. Schafers, M. Eisenblatter and M. Wildgruber, “Multispectral optoacoustic tomography of the human breast: characterisation of healthy tissue and malignant lesions using a hybrid ultrasound-optoacoustic approach,” Eur Radiol. vol. 28, no. 2, pp. 602 -609, 2018.

G.A. Milikan, “The Oximeter, an instrument for measuring continuously the oxygen saturation of arterial blood in man,” Review of Scientific Instruments, vol. 13, pp. 1-7, 1942.

M. Nitzan, S. Noach, E. Tobal, Y. Adar, Y. Miller, E. Shalom and S. Engelberg, “Calibration-Free Pulse Oximetry based on two wavelengths in the Infrared - A preliminary study,” Sensors, vol. 14, no. 4, pp. 7420-7434, 2014.

G.D. Perkins, D.F. McAuley, S. Giles, H. Routledge and F. Gao, “ Do changes in pulse oximeter oxygen saturation predict equivalent changes in arterial oxygen saturation?,” Critical Care, vol.7, pp. 67-71, 2003.

M.H. Smith, “Optimum wavelength combinations for retinal vessel oximetry,” Applied Op¬tics, vol. 38, pp. 258-267, 1999.

A. Huong, I.M. Stockford, J.A. Crowe and S.P. Morgan, “Investigation of optimum wavelengths for oximetry,” in Proceedings of SPIE: OSA Biomedical Optics, vol. 7368, pp. 1-7, 2009.

N. Rajaram, T. Nguyen and J.W. Tunnell, “Lookup table based inverse model for determining optical properties of turbid media,” Journal of Biomedical Optics, vol. 13, pp. 0505011-3, 2008.

X. Zhong, X. Wen and D. Zhu, “Lookup-table-based inverse model for human skin reflectance spectroscopy: two-layered Monte Carlo simulations and experiments,” Optics Express, vol. 22, pp.1852-1864, 2014.

T. Chen, P. Yuen, M. Richardson, Z. She and G. Liu, “Wavelength and model selection for hyperspectral imaging of tissue oxygen saturation,” The Imaging Science Journal, vol. 63, pp. 1-7, 2015.

K.A. Firn and B. Khoobehi, “Noninvasive Multispectral snapshot imaging system to measure and map the distribution of human retinal vessel and tissue hemoglobin oxy¬gen saturation,” International Journal of Ophthalmic Research, vol. 1, pp. 48-58, 2015.

A. Huong and X. Ngu. “The application of extended modified Lambert Beer model for mea¬surement of blood carboxyhemoglobin and oxyhemoglobin saturation,” Journal of Innovative Optical Health Sciences, vol.7, pp. 145002641-7, 2014.

A. Huong, Spectroscopic analysis of scattering media via different quantification tech¬niques: University of Nottingham, 2012.

I.V. Meglinski and S.J. Matcher, “Quantitative assessment of skin layers absorption and skin reflectance spectra simulation in the visible and near-infrared spectral regions,” Physiol. Measurement, vol. 23, no. 4, pp. 741- 753, 2002.

L. Meng, W.W. Mantulin, B.S. Alexander, A.E. Cerussi, B.J. Tromberg, Z. Yu, K. Laning, Z.N. Kain, M. Cannesson and A.W. Gelb, “Head-up tilt and hyperventilation produce similar changes in cerebral oxygenation and blood volume: an observational comparison study using frequency-domain near infrared spectroscopy,” Can J Anesth., vol. 59, pp. 357-365, 2012.

D. Yim, G.V.G. Baranoski, B.W. Kimmel, T.F. Chen and E. Miranda, “A cell-based light inter¬action model for human blood,” Eurographics, vol. 31, pp. 845-854, 2012.

V.M. Niemeijer, R.F. Spee, J.P. Jansen, A.B.C. Buskermolen, T.V. Dijk, P.F.F. Wijn and H.M.C. Kemps, “Test retest reliability of skeletal muscle oxygenation measurements during submax¬imal cycling exercise in patients with chronic heart failure,” Clin Physiol Funct Imaging, vol. 37, pp. 68-78, 2017.




DOI: http://doi.org/10.11591/ijeecs.v19.i2.pp%25p
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