Self-diagnostic approach for cell counting biosensor

Abstract

In this research, a test monitoring strategy for an array of biosensors is proposed. The principle idea of this diagnostic technique is to measure and compare the impedance of each sensor in the array to achieve fully controlled online health monitoring technique at the system level. The work includes implementation of the diagnostic system, system architecture for analogue part, and SNR analysis. The technique has been applied on a cell coulter counting biochip where the design and fabrication of this sensing chip with electrodes make the coulter counter be an effective mean to count and analyses the cells in a blood sample. The experimental results show that the indication factor of the sensing electrodes has increased from 1 to 1.8 gradually depending on the fault level.